|This article is about a/an organization in Kamen Rider 555.|
Smart Brain (スマートブレイン Sumāto Burein?) is a company that is a front for a group of Orphnoch that sees themselves as the master race and are dedicated to the genocide of the human race and increase of the Orphnoch population. They experiment in making their race even more powerful and developing weapons that only Orphnoch can use. Smart Brain is ironically where the Rider Gears were developed from. This is the largest coordinated group of Orphnoch ever seen, and in the movie Paradise Lost they seem to have formed a de-facto world government after the Orphnoch revolution.